The Department of Chemistry and Physics kicks off its Fall Seminar series next week. Details for this virtual Zoom talk are given below.
Dr. Deborah C. Bebout
Professor & Associate Chair of Chemistry
Department of Chemistry, College of William & Mary
Join from PC, Mac, Linux, iOS or Android: https://tennessee.zoom.us/j/3854759120
Metallothionein-Inspired Coordination Chemistry
Metallothioneins (MTs) are taxonomically widespread small cysteine-rich proteins with roles in the metabolism of essential metals and protection against metal toxicity. These proteins are associated with distinct binding domains for thiolate-bridged metal clusters. Remarkably few synthetic analogs of these clusters have been prepared outside of proteins. Mixed aromatic amine, monothiolato ligands have been used as synthons for homo- and heterometallic MT-like group 12 complexes, as well as unexpected alternatives. New complexes have been characterized by a combination of X-ray crystallography, 1H NMR and electrospray ionization mass spectrometry. Successful strategies for encouraging MT-like clusters to crystallize will be described.